Individualized chemotherapy for colorectal cancer
نویسندگان
چکیده
منابع مشابه
Genetics and Individualized Treatment for Colorectal Cancer
The clinical benefit of the genomics revolution is particularly evident in oncology. Genetic characterization of patients’ tumors has revealed that cancer is fundamentally a heterogeneous disease whose complex clinical course can be correlated to specific molecular profiles. Now, genomic data and tools are beginning to be translated from the laboratory to the clinic where physicians and patient...
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Several randomized trials have shown superior response rates for 5-fluorouracil (5-FU) combined with folinic acid as compared to 5-FU alone. Both treatment regimens are well tolerated and generally can be applied in an outpatient setting. To date no other tested drug combination as methyl-CCNU (M), vincristine (O) and 5-FU (MOF), cisplatin and 5-FU (DDP/5-FU) or methotrexate and 5-FU (MTX/5-FU)...
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Colorectal cancer is the second leading cause of cancer death. Approximately 26,000 new cases are diagnosed yearly in France, resulting in more than 10,000 deaths, and 5-year survival remains low, at 40%. This poor prognosis is partly due to the fact that, in 30% of cases, colorectal cancer is metastatic or at a locally advanced stage when discovered. Moreover, visceral metastases complicate th...
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Colorectal cancer (CRC) is the fourth most common malignancy in the United States (1). Approximately 130,000 new patients will be diagnosed with this cancer in 1999. It is the second leading cause of cancer death, with 55,000 patients expected to die of it. Most patients die of metastatic disease. The vast majority of them have liver as the dominant site of metastases (2). Approximately 30% of ...
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Colorectal cancer (CRC) is a highly prevalent malignant disease in industrialized nations. The annual incidence of invasive CRC in the U.S. is among the highest in the world, and the liver is the only metastatic site in approximately one third of patients. Without treatment, patients with metastatic disease have a poor prognosis; however, long-term survival benefits and even cure have been repo...
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ژورنال
عنوان ژورنال: Juntendo Medical Journal
سال: 2008
ISSN: 0022-6769,2188-2134
DOI: 10.14789/pjmj.54.16